解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIMS:Here we report two cases of follicular lymphoma that transformed to CD30 positive diffuse large B cell lymphoma and review the literature on this topic. RESULTS:The first case represents an example of early transformation of conventional low-grade follicular lymphoma to CD30-positive large B cell lymphoma. Immuno...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12733
更新日期:2015-12-01 00:00:00
abstract:AIMS:Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a downstream effector of Ras signalling, and is overexpressed in several types of human malignancy. However, its role in gastric cancer remains unclear. The aim of this study was to investigate the prognostic significance of G3BP1 in gastric can...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12695
更新日期:2015-11-01 00:00:00
abstract:AIMS:To compare the clinical and pathogenetic differences between high-grade (HG) endometrioid carcinomas with and without concurrent low-grade (LG) components. METHODS AND RESULTS:The expression of ARID1A, PTEN, p53 and mismatch repair (MMR) proteins in HG endometrioid carcinomas without (n = 19) or with (n = 22) con...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12664
更新日期:2015-10-01 00:00:00
abstract:AIMS:The available evidence indicates that most non-uterine high-grade serous carcinomas (HGSCs) arise from the fallopian tube (FT), but approaches to primary site assignment have not evolved to reflect this. The aim of this study was to assess the application of recently proposed criteria for site assignment. METHODS...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12651
更新日期:2015-09-01 00:00:00
abstract:AIMS:To investigate redox-regulating enzymes that may have a special role in melanoma pathogenesis due to continuous exposure to microenvironment-produced and ultraviolet radiation-induced oxidative stress. METHODS AND RESULTS:We assessed immunohistochemically the expression of antioxidant enzymes peroxiredoxins (Prxs...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12659
更新日期:2015-09-01 00:00:00
abstract:AIMS:The majority of patients with Down syndrome (DS), trisomy 21, have morphologically abnormal thymuses and present with intrinsic immunological abnormalities affecting mainly the cellular immune response. The aim of this study was to examine whether the expression of functionally important molecules is altered in th...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12642
更新日期:2015-08-01 00:00:00
abstract:AIMS:In order to develop efficient digital pathology workstations, we studied the navigation patterns of pathologists diagnosing whole-slide images. To gain a better understanding of these patterns, we built a conceptual model based on observations. We also determined whether or not new navigation patterns have emerged...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12629
更新日期:2015-08-01 00:00:00
abstract:AIMS:To estimate the likelihood of the upgrade for atypical ductal hyperplasia (ADH) diagnosed on a core needle biopsy of a mammographically detected lesion. METHODS AND RESULTS:A total of 203 consecutive ADH cases diagnosed on core biopsy in mammographically detected lesions and having subsequent surgical excision we...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12635
更新日期:2015-07-01 00:00:00
abstract:AIMS:Pulmonary adenosquamous carcinoma (ASC) is more aggressive than adenocarcinoma (AC) and squamous cell carcinoma (SCC). The genetic features and biomarkers of ASC are not well known. Here, we attempted to identify potential therapeutic markers for ASC. METHODS AND RESULTS:Surgically resected ASC samples from 65 pa...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12556
更新日期:2015-06-01 00:00:00
abstract:AIMS:This study aimed to assess the feasibility of using virtual slides to create 3D histopathological reconstructions to aid in the study of the biology of DCIS. METHODS:Four μm thick serial sections of formalin fixed paraffin embedded tissue from three cases were cut and mounted onto glass slides, stained with haema...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12561
更新日期:2015-06-01 00:00:00
abstract:AIMS:Alterations in the expression of several long non-coding RNAs (lncRNAs) have been found in primary nasopharyngeal carcinoma (NPC). However, the effect of lncRNA expression on primary NPC as well as the molecular mechanism of lncRNA remains vague. This study was to identify differentially expressed lncRNAs involved...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12616
更新日期:2015-06-01 00:00:00
abstract:AIMS:The current WHO classification of thymic epithelial neoplasms describes type A and type AB thymomas as behaving 'like benign neoplasms'. However, recent published data suggest that rare cases may show more aggressive behaviour. The aim of this study was to assess the frequency of atypical cases, and to determine w...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12512
更新日期:2015-05-01 00:00:00
abstract:AIMS:Telomerase is reactivated in most cancers and there is accumulating evidence that this is a driver event in malignant melanoma (MM). Thus, our aim was to evaluate if in-situ hybridization (ISH)-based quantification of telomerase RNA (hTR) could be used to distinguish MM from naevi, and if there was a correlation w...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12501
更新日期:2015-04-01 00:00:00
abstract:AIMS:To assess the outcome of breast papillary lesions diagnosed by ultrasound-guided core needle biopsy (CB) or vacuum-assisted 'mammotome' biopsy (MT), the accuracy of these diagnoses, and whether it is justified not to undertake surgical excision of non-malignant papillary lesions so diagnosed. METHODS AND RESULTS:...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12477
更新日期:2015-03-01 00:00:00
abstract:AIMS:The aim of this study was to examine clinicopathological features of patients with core biopsy diagnoses of ductal carcinoma in situ (DCIS) that may predict invasion on subsequent excision, as upstaging has significant implications regarding the need for axillary staging via sentinel lymph node biopsy (SLNB). MET...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12550
更新日期:2015-03-01 00:00:00
abstract:AIMS:Pulmonary sequelae, reported as chronic graft-versus-host disease (cGVHD), of haematopoietic stem cell transplantation (HSCT) include constrictive bronchiolitis obliterans (CBO), lymphocytic bronchiolitis (LB), and veno-occlusive disease (VOD); recently, pleuroparenchymal fibroelastosis (PPFE) has also been descri...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12553
更新日期:2015-03-01 00:00:00
abstract:AIMS:Y-box binding protein-1 (YB-1) is known to modulate gene transcription and protein translation, as well as cellular response to drug treatment. The aim of this study is to correlate YB-1 protein expression levels with clinicopathological parameters in intestinal-type gastric cancer tissue samples (as categorized b...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12570
更新日期:2015-03-01 00:00:00
abstract:AIMS:To compare the expression and prognostic value of the cell cycle markers Aurora kinase A (AURKA) and Ki67 in neuroblastoma, because AURKA expression levels have greater prognostic significance than those of Ki67 in some cancers. METHODS AND RESULTS:Eighty-eight neuroblastomas were immunostained with anti-AURKA an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12520
更新日期:2015-02-01 00:00:00
abstract:AIMS:There is increasing evidence of Gleason score (GS) drift in prostatic core biopsies during the last two decades. The ProtecT study is a randomized controlled study and provides an excellent cohort to study the effect of time, prostate-specific antigen (PSA) level, perineural invasion, tumour length and age on GS. ...
journal_title:Histopathology
pub_type: 杂志文章,随机对照试验
doi:10.1111/his.12549
更新日期:2015-02-01 00:00:00
abstract:AIMS:To evaluate the immunoexpression of cyclin A1 in pT1 urothelial carcinomas of the bladder (UC) from a cohort of patients treated by transurethral resection of the bladder (TURB), to determine its value in predicting tumour recurrence, tumour progression, or systemic metastases. METHODS AND RESULTS:Five tissue mic...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12499
更新日期:2015-01-01 00:00:00
abstract::A large variety of lymphoma types may develop as primary intestinal neoplasms in the small intestines or, less often, in the colorectum. Among these are a few entities such as enteropathy-associated T-cell lymphoma or immunoproliferative small intestinal disease that, essentially, do not arise elsewhere than in the ga...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12596
更新日期:2015-01-01 00:00:00
abstract:AIMS:Rosai-Dorfman disease (RDD) commonly occurs in lymph nodes, but it can also affect the genitourinary (GU) system. In a search of GU RDD, we identified three cases involving the testis and three the kidney. METHODS AND RESULTS:The mean age was 52.4 (35-76) years. Tumour sizes were 3.6 cm on average (1.5-4.3) for t...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12494
更新日期:2014-12-01 00:00:00
abstract:AIMS:The handling and examination of sentinel lymph nodes (SLNs) to detect metastasis is critical in the assessment of early breast cancer patients. This survey investigates the variation in practise followed by pathology units across the United Kingdom in the staging evaluation of axillary lymph nodes (ALNs). METHODS...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12440
更新日期:2014-11-01 00:00:00
abstract:AIMS:Neoadjuvant radiochemotherapy (RCT) followed by surgical resection is the treatment for locally advanced mid-rectal or low rectal cancer. The aim of this study was to evaluate postoperative histological prognostic factors in a series of surgical specimens after neoadjuvant RCT. METHODS AND RESULTS:One hundred and...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12432
更新日期:2014-11-01 00:00:00
abstract:AIMS:Pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) are two metabolic and oncogenic markers of cancer. In this study, we sought to investigate their expression patterns and prognostic value in tongue squamous cell carcinoma (TSCC). METHODS AND RESULTS:The expression and subcellular localization of PKM2 a...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12441
更新日期:2014-11-01 00:00:00
abstract:AIMS:To verify the applicability, reproducibility and predictive value of a proposed unified classification (amended Ljubljana classification) for laryngeal squamous intraepithelial lesions (SILs). METHODS AND RESULTS:Six internationally recognized experts and three pathologists from Ljubljana contributed to this stud...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12427
更新日期:2014-10-01 00:00:00
abstract:AIMS:Hodgkin lymphoma treatments are largely based on the generation of reactive oxygen species, but increased expression of antioxidant enzymes may contribute to chemoresistance. The aims of this study were: to define the extent and prognostic value of oxidative stress marker and antioxidant enzyme expression in Hodgk...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12389
更新日期:2014-09-01 00:00:00
abstract::The use of percutaneous renal tumour biopsy (RTB) as a diagnostic tool for the histological characterization of renal masses has increased dramatically within the last 30 years. This increased utilization has paralleled advances in imaging techniques and an evolving knowledge of the clinical value of nephron sparing s...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12495
更新日期:2014-09-01 00:00:00
abstract:AIM:Special AT-rich sequence-binding protein 1 (SATB1) is a cell type-specific matrix attachment region binding protein, functioning as a global genome organizer. This study aims to investigate the expression pattern and the prognostic value of SATB1 in colorectal cancer. METHODS AND RESULTS:Prospectively collected da...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12295
更新日期:2014-08-01 00:00:00
abstract:AIMS:To address whether napsin A is useful for identifying metastatic adenocarcinomas of pulmonary origin. METHODS AND RESULTS:Fifty-four cases of adenocarcinoma that metastasized from the lungs to various sites and 1762 cases of carcinoma from various organs were immunostained for napsin A, TTF-1, CK7, CK20 and CDX2 ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12383
更新日期:2014-08-01 00:00:00
abstract:AIMS:Owing to their close embryological relationship, soft tissue perineurioma and meningioma may closely mimic each other, not only histologically but also by immunohistochemistry. We aimed to compare the frequency of perineurial marker expression in these two entities, and to determine whether somatostatin receptor 2...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12366
更新日期:2014-07-01 00:00:00
abstract:AIMS:It is known that thyroid transcription factor-1 (TTF-1) is expressed in a small percentage of primary gynaecological adenocarcinomas. Following the observation of TTF-1 positivity in a number of endometrioid adenocarcinomas of the uterine corpus which behaved aggressively, we undertook immunohistochemical staining...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12332
更新日期:2014-05-01 00:00:00
abstract:AIMS:Pathology specimens often contain important margins that must be identified from gross examination of specimens through to microscopic examination. Commonly, unique colours of tissue-marking dye (TMD) are applied to each margin, which facilitates both macroscopic and microscopic identification. Various techniques ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12328
更新日期:2014-05-01 00:00:00
abstract:AIMS:The morphological criteria for identification of intercalated duct lesions (IDLs) of salivary glands have been defined recently. It has been hypothesised that IDL could be a precursor of basal cell adenoma (BCA). BCAs show a variety of histological patterns, and the tubular variant is the one that presents the str...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12339
更新日期:2014-05-01 00:00:00
abstract:AIMS:In oesophageal adenocarcinoma, detection rates of venous invasion using haematoxylin and eosin (H&E) and elastic stains have not been compared. The aims of this study were to investigate whether or not elastic stains facilitate the detection of venous invasion, and to determine the prognostic significance of venou...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12308
更新日期:2014-04-01 00:00:00
abstract:AIMS:To look for FOXL2 mutation in rare ovarian epithelial lesions showing stromal components with morphological features of adult granulosa cell tumour (AGCT). METHODS AND RESULTS:We report the 402C→G FOXL2 mutation status in five epithelial ovarian lesions in women aged 45-77 years showing stromal proliferations tha...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12314
更新日期:2014-04-01 00:00:00
abstract:AIMS:SOX2 is a key regulatory gene in embryonic stem cells. Although it has been implicated in cancer progression, its role in breast carcinoma is poorly understood. MATERIALS AND METHODS:Fifty-seven ductal carcinomas in situ (DCIS), 552 invasive breast carcinomas and 107 corresponding metastatic lymph nodes were eval...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12257
更新日期:2014-03-01 00:00:00
abstract:AIMS:The great majority of ovarian clear cell carcinomas have a hepatocyte nuclear factor 1 homeobox B (HNF-1β)-positive and oestrogen receptor (ER)-negative immunoprofile. However, the pattern of HNF-1β and ER immunostaining in clear cell carcinomas of the endometrium and the usefulness of this panel in distinguishing...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12286
更新日期:2014-03-01 00:00:00
abstract::Alongside histomorphology and immunohistochemistry, molecular pathology is now established as one of the cornerstones in the tissue diagnosis of bone tumours. We describe the principal molecular pathological techniques employed, and each of the bone tumour entities where their identified characteristic molecular patho...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12275
更新日期:2014-03-01 00:00:00
abstract:AIMS:Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin superfamily. Although its overexpression in various cancers has been reported, little is known about its expression and clinical significance in oral squamous cell carcinoma (OSCC). This study aimed to elucidate the clinical significanc...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12293
更新日期:2014-02-01 00:00:00